Academic positions

Junior Researcher PhD position in Veterinary Comparative, Regenerative and Translation Biomedicine Research

Proposed Thesis title & description:

Mesenchymal Stem Cells Derived Extracellular Vesicles Based Targeted Therapy for Bovine Endometritis

More than 50% of early pregnancy losses happening may be due to various complications with endometrial conditions, pathologies, receptivity, embryo development and foetal development related complications. From endometrial pathological perspectives, both clinical and sub-clinical endometritis have become as key disease impacting cow fertility. A growing method in recent years has been the use of veterinary regenerative medicine approach using adult stem cells and   extracellular vesicles (EV) as a diagnostic and therapeutic tool for many animal diseases. Mesenchymal stem cells (MSC) have been selected as a key regenerative approach since almost all postnatal tissues, irrespective of the regenerative capacity. Bovine (Bos taurus) MSC-EVs are nano-scale entities carrying various cargoes and are believed to be involved in intercellular communications. Particularly related to the endometritis, different types of isolated EVs have demonstrated potential applications in the modulation of the immune responses in different animal models and in in vitro works. Thus, in this doctoral research work we would expect to explore the use of bovine bone marrow derived MSC-EVs as a therapeutic/prophylactic intervention for endometritis and to improve cow fertility using both advanced in vitro and in vivo research models.

Study period: Four years full time basis (1.00)

Qualification of the candidate:

  • Competition is open for both local and international students who fulfil the basic doctoral school admission requirements stipulated by the Estonian University of Life Sciences, Estonia. Please visit the web link for more information:https://www.emu.ee/en/admissions/doctoral-studies/admission-requirements/ 
  • Possession of the first degree plus master’s degree level qualification in human medicine, veterinary medicine, agriculture, animal science or biological sciences streams.
  • Experience in cell cultures and basic cell & molecular biology techniques.
  • Experience in working with extracellular vesicles (not essential but preferable)
  • Experience in transcriptomics and proteomics work with basic bioinformatics knowledge (not essential but preferable)
  • Experience in publishing research outcomes in conferences and reputed scientific journals (not essential but preferable)
  • Fluency in writing and speaking in English

Research Team: COMBIVET ERA chair and OH-BOOST are EU funded research projects that are being run by a multidisciplinary research team with proven track record on high-quality cutting-edge research on extracellular vesicles based in Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu Estonia. For more information please visit: https://www.combivet.ee/   and https://sites.google.com/view/ohboost/home

What we offer: A four year fully funded tuition free PhD position for ideal candidate with a monthly salary of EUR 1718 (pre-tax) with other fringed benefits attached to junior research fellow position at the EMU and under Estonian government regulations.

For more information:

 Please contact Dr. Suranga Kodithuwakku suranga@emu.ee or Professor Alireza Fazeli  alireza.fazeli@emu.ee

 

 

PhD position in Veterinary Comparative, Regenerative and Translation Biomedicine Research

Proposed Thesis title & description:

Development of Milk Extracellular vesicles for therapeutic applications

Extracellular vesicles (EVs) are tiny lipid bilayer membrane vesicles in the range of 50 to 1000 nano-metres. All cells seem to produce EVs and they exist in nearly all bio-fluids. The exact function of EVS in biological systems is not known. They seem responsible for cell-to-cell communication. EVS have also been reported to have different effects from immunomodulatory effects to protection of cells and supporting the cell viability. Milk is a natural biofluid that have been consumed by humans from ancient times. Milk is the only food that has evolved to meet the nutritional needs of newborns, supporting growth and development while also being a significant source of nutrients in adults. There is a considerable interest in milk-derived EVs and their cargoes. Cow milk EVs influence biological functions by regulating biochemical pathways and/or interactions with the host’s gut microbiome. Several researchers have reported the effects of milk EVs on the gut microbiota, in the immune response, in diseases such as cancer, and in other aspects of cell biology. Thus, the main aim of the project is to facilitate development of milk EV based therapeutic applications for treatment of different digestive tract anomalies and diseases. To achieve this goal, we aim to test several hypothesises to further progress cow milk EVs application as a treatment for human digestive tract diseases and anomalies using advanced in vitro experimental work

Study period: Four years full time basis (1.00)

Qualification of the candidate:

  • Competition is open for both local and international students who fulfil the basic doctoral school admission requirements stipulated by the Estonian University of Life Sciences, Estonia. Please visit the web link for more information: https://www.emu.ee/en/admissions/doctoral-studies/admission-requirements/    
  • Possession of the first degree plus master’s degree level qualification in human medicine, veterinary medicine, agriculture, animal science or biological sciences streams.
  • Experience in cell cultures and basic cell & molecular biology techniques.
  • Experience in working with extracellular vesicles (not essential but preferable).
  • Experience in transcriptomics and proteomics work with basic bioinformatics knowledge (not essential but preferable).
  • Experience in publishing research outcomes in conferences and reputed scientific journals (not essential but preferable).
  • Fluency in writing and speaking in English.

Research Team: COMBIVET ERA chair and OH-BOOST are EU funded research projects that are being run by a multidisciplinary research team with proven track record on high-quality cutting-edge research on extracellular vesicles based in Institute of Veterinary Medicine and Animal Science, Estonian University of Life Sciences, Tartu Estonia. For more information please visit: https://www.combivet.ee/  and https://sites.google.com/view/ohboost/home

What we offer: A four year fully funded tuition free PhD position for ideal candidate with a monthly salary of EUR 1718 (pre-tax) with other fringed benefits attached to junior research fellow position at the EMU and under Estonian government regulations.

For more information:

 Please contact Professor Alireza Fazeli  alireza.fazeli@emu.ee or Dr. Suranga Kodithuwakku suranga@emu.ee